Welcome to the thread! Make yourself at home, we have copious amounts of tea and large amounts of stupid

It is indeed an escort ship, clocking in at 37mm at this moment in time. I am also indeed intending to make silicone moulds to make resin castings. Not in very high numbers, I imagine, so less of the hurry of a production environment... Will the freedom to take my time help reduce casting problems?
For the engines, I appreciate that I'm asking for trouble, but if needed I can always fill them at a later stage and make a new mould. Most of the windows are fairly shallow, and the direction of moulding should help keep those areas intact. Only the fore wings (blue section) have undercuts at the mould line, which I expect will cause the most wear. (I may be wrong?)
For the guns... I'm really, really, hoping to get away with having barrels on the small turrets. They're as close to a cube as it goes, so I'm hoping they'll be ok. I don't want to live in a reality where I can get better details scratchbuilding than casting! This one will be tougher to fix post-print if it does cause issues, but at these proportions, will it? The domes are about 0.8mm diameter, while the barrels are in the 0.2*0.2*0.2 range if I'm not mistaken. Accurate dimensions in this thread somewhere...
The larger QF turrets are going to have barrels added during assembly, because they're the wrong sort of shape (long thin cylinder shape) to cast reliably and without damaging at some point. They'll just be ordinary styrene rod stock. The main guns with actual barrels... Possibly also going to be stock, though thicker. Not sure if those barrels would cast any better (not done the measurements for those yet).
I'd absolutely love to print this actual size and get a good look at it, and I'd probably go back in and strip out certain bits of detail, but unfortunately this is a luxury that simply isn't available to me. I don't have direct access to any 3D printer, let alone the exact type/make/model of printer that it will eventually come out of. I'm kind of willing to write the first print+cast off as an experiment; though I do hope it won't be a complete waste. If some of the details are wasted, that's fine by me. If the mould doesn't live as long as it could have, that's fine by me. If it doesn't come together when it comes out of the mould, or if the mould is destroyed after the first or even fifth, that's less cool. Do you think I can manage to meet those sorts of goals?

Your professional input has been very helpful, and is much appreciated!