Right okay, sorry for the wait but this needs resolving.
With regards to hurl opponent, you should declare your intention to use this skill before resolving the effects of the combat. The reason being is that there are obvious perks and disadvantages to using hurl opponent, and it is not something you will always want to do. Therefore as a skill you can use you have to declare its use before rolling - it is the only fair way to do it!
Resolve the combat as you would any other, and if the model with the hurl opponent skill wins the combat, they will hurl the opponent, regardless of effects. Because the model is being ejected from the combat as part of the "resolving attacks" part of the combat, the victim will be hurled regardless of other wound results (even down or out of action), and if not taken out of action with the wounds, will suffer collateral damage from throws and falling damage from the throw.
As the model is thrown, the model cannot be taken out of action on a down result, although the downed result would still stand, providing the injury status does not change after resolving throw damage.
If as part of a multiple combat, the result is the same, and you would declare before resolving that part of the combat (so you would say "I intend to use Hurl Opponent on enemy A", but you may choose not to for enemy B or vice versa). If by massive good fortune you threw out one or more enemies out of combat and the other remaining enemies were taken down as part of the combat, yes, they would go out of action (remember though that ejected or downed enemies still add cumulative bonuses to fighters with the outnumber bonus in combat!).
As to resolving the throw, the ability is a muscle skill, and the ORB states as follows:
If you win a round of combat, instead of hitting your opponent you can throw him D6" in the direction of your choice. The thrown model takes a single hit equal to half the distance rolled. If it hits a solid object (such as a wall) before it reaches the full distance thrown it will stop there. If it hits another model, then both models take a hit equal to half the distance rolled. - ORB pg 90.
And this is the one from the Pit Slaves rules:
Pit Slave armed with a claw may pick up and hurl his opponent if he wins a round of hand-to-hand combat. This hurl is in addition to hitting his opponent. A hurled opponent is thrown D6†in a direction chosen by the Pit Slave player and suffers a single hit at the strength equal to half the distance hurled (round up). If the hurled opponent strikes a wall or other obstacle he will stop there. If the hurled opponent hits another fighter then both fighters take a single hit with a strength equal to half the distance hurled. If the hurled opponent is pitched off a building use the Advanced Rules for Falling found on page 27 of the Necromunda LRB. Pit Slaves V2 p.7
You'll note the difference in rulings that the issue does not happen with a regular hurl opponent skill, where the throw is done
instead of hitting your opponent. Regardless, the rules for throwing are about the same. You choose a direction, and the model is thrown D6" in that direction. Any obstacles in the way (including other fighters) will be automatically hit and each take a single hit equal to half the distance hurled.
You would determine the direction before resolving the distance (as this is the fairest way to do it, and a logical order), and bear in mind the constraints of LOS or blocking - you wouldn't be able to throw a model the direction covered by another enemy in combat - this would greatly limit your vision for many reasons.
There are benefits to either of the hurl opponent rules, but the only way to fully solve this is if Arbitrator General posts up as to whether the difference in rules was intentional or not, but he's a very busy guy.
We usually play Warhammer 40.000 and we all are freaks about rullings, spelling etc. So Necromunda gives us all a big, wet kick into ass. You can make ten interrpretacions of every unusual rule:)
Funny, I've found 40k very poor for rulings and consistent rules concepts. At least Necromunda has a system that solves most of its own problems.